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The first three mutations are also found as polymorphisms in untreated persons, occurring in 4%, 4%, and 1% of untreated persons, respectively.

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The trend in counts is more important than any single value; a 30% or greater change in the absolute CD4 count between tests, or a 3-percentage point change in the CD4 percentage, is considered clinically significant.

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Later reviews in the late 90s and early 2000s noted that this approach of "hit hard, hit early" ran significant risks of increasing side effects and development of multidrug resistance, and this approach was largely abandoned.

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